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451 4.4.0 - 421 Mailbox unavailble 2007-2010 on both servers

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Hi,

there two domains, whis Exchange 2007 and Exchange 2010. 

suddenly - in message queue. Massages stuck:

451 4.4.0 Primary target IP address responded with: 421 Mailbox unavailable attempted failover to alternate host..., on both servers




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